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Trime & Bond ŽNT is the successor to Prime & Bond 2.1 and is the best 5th generation bonding agent. It is truly a one coat technique and this is accomplished by several mechanisms:

1. The overall resin concentration has been raised
2. A small resin (D-resin) has been added
3. A crosslinking agent (T-Resin) has been added
4. A nanofiller has been added

The nanofiller is extremely small, and is only about 7nm in diameter and hence it reaches all the places the liquid components of Prime & Bond ŽNT reaches. Figure 4 shows the comparative sizes of the Nanofiller to the size of a Dyract ŽAP particle of about 0.8ľm. It is evenly distributed in the resin matrix when cured and serves as an additional crosslinker and adds to the strength of the adhesive layer and the hybrid layer. The average dentinal tubule is about 0.8ľm and the channels between the collagen fibrils in acid conditioned dentine is about 20nm wide with a diameter of 5-10nm. The nanofiller has therefore the perfect size to penetrate these channels to provide added "Nano-retention". The filled adhesive is stronger than unfilled adhesive and when infiltrated into conditioned dentine, it provides the polymeric toughness as well as strength.

The higher bond strengths of Prime & Bond ŽNT to enamel and dentine using both the Spectrum TPH and Dyract ŽAP have been extensively demonstrated by several of the world's leading authorities. When the adhesion of five of the current leading "5th generation" bonding agents to enamel and dentine were compared, Prime & Bond ŽNT recorded the highest bond strength by a good margin.

Prime & Bond ŽNT also improved the fluoride release mechanism from an initial burst of fluoride release to a more gradual, but higher level of fluoride release over a longer time period.

Dr. J Perdigao (Univ. of N. Carolina) concluded that "Prime & Bond ŽNT consistently formed fully-penetrated, "filled" hybrid layers, filled resin tags and penetrated laterally into secondary canals."

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